The Chemical Biology Thematic Group is engaged in a diverse range of research topics, which span structural biology, enzymology, nucleic acid research, signalling pathways, single molecule biophysics, and biophysical chemistry of living tissues. Among the themes that unite the research being performed in this group is the attempt to learn new chemistry and physics from biological systems. We have projects relating to pharmaceutically relevant enzymes such as those involved in drug metabolism and antibiotic resistance; development of therapeutic agents in the control of inflammation, cancer, and viral infections; the chemical biology of NO; quantification of bioenergetic markers of metabolism; self-assembly mechanisms of the HIV-1 virion capsid; liposome microarray systems to address membrane protein dynamics and recognition; studies on reactive oxygen species translocation across the aqueous/lipid membrane interface; RNAi/antisense technologies; dynamic combinatorial chemistry; protein dynamics and function; mechanistic aspects involved in cellular adhesion and transport in membrane and zeolite channels; and cutting-edge microscopes used to examine transport, motility, and reactivity in cells.
化学生物专题小组从事各种各样的研究课题，包括结构生物学、酶学、核酸研究、信号通路、单分子生物物理学和生物物理化学。在这一组中进行的研究的主题之一是从生物系统中学习新的化学和物理知识的意图。我们的专业具备以下条件：与药学相关的酶，如那些参与药物代谢和抗生素耐药性;在控制炎症,癌症,和病毒感染的治疗药物的发展;锘化学生物学;量化代谢的生物能量学标记;hiv - 1病毒衣壳的自组装机制;处理膜蛋白动力学和辨认的脂质体微阵列系统; 在水/脂质膜界研究活性氧易位面;RNAi /反义技术;动态组合化学;蛋白质动力学和功能; 参与了膜的细胞粘附和运输和沸石渠道等机械方面;和用于检查运输、运动性和反应性细胞的尖端显微镜。